ASCENT-03 allowed crossover. TRO-Breast02 didn’t.
This one design difference dramatically affects how we interpret OS — and why OS may never be seen in ASCENT-03.
Drs. Iyengar and Hamilton break down how crossover supports patient-centered care but complicates long-term survival interpretation.
Crossover Confusion: ASCENT-03 OS Data Complication
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