Redefining HER2: From Oncogene Discoveryto Clinical Breakthrough

In this CHM Conversations segment, Dr. Bardia explores the historical evolution of HER2, highlighting key milestones from the discovery of the HER2 oncogene to the development of trastuzumab. He provides clarity on the shifting definitions and diagnostic criteria that are shaping modern breast cancer treatment.

Topics Covered:
• Historical milestones in HER2 discovery
• Diagnostic evolution (IHC and FISH criteria)
• Clarifying HER2 positivity vs negativity in a non-binomial nature