The Frontline Face-Off: DB-09, PATINA, and HER2CLIMB-05

Cross-trial comparisons in HER2+ mBC are getting complex as we move beyond the old “one-size-fits-all” frontline approach.

While PATINA and HER2CLIMB-05 focus on intensifying the maintenance phase, DESTINY-Breast09 challenges the entire paradigm by leading with an ADC from the start. This clip explores how induction requirements and endocrine therapy use influenced these results—and why the “best” strategy depends on how you define success.