What Happens After T-DXd? Sequencing Without a Playbook

As first-line therapy delivers longer and deeper responses, the old treatment algorithms are starting to break.

This clip dives into real-world sequencing after T-DXd — including rechallenge considerations, HER2CLIMB regimens, taxanes, CDK4/6 combinations, and why deviating from trial protocols may mean patients never fully realize the 40-month benefit seen in DESTINY-Breast09.